A type of abnormal heartbeat (prolonged QT interval) can happen with Zofran (ondansetron injection). Call your doctor right away if you have a fast heartbeat , a heartbeat that does not feel normal, or if you pass out. How to use Zofran Vial. To prevent nausea from chemotherapy, ondansetron is mixed in a solution and given by injection into a vein as directed by your doctor, usually over 15 minutes. I knew I would be in trouble with that last post. You are right, thanks! I was thinking of the Zofran tablets anyway. They have been really easy to dissolve under almost any kid's tongue. What other drugs will affect Zofran? Zofran can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. How to use Zofran. To prevent nausea from chemotherapy, take this medication by mouth usually within 30 minutes before treatment begins. To prevent nausea from radiation treatment, take this. Get a script for ondansetron (Zofran) to keep from heaving, as you probably can't vomit and would just keep putting pressure on your wrap. Many of us just keep this on hand, with us all the.Stay off the alcohol as much as you can. You can read about these if you search on the words in parenthesis. One of my Dr.s' agreed today to put me on Naltrexone to see if it will help eleminate the cravings. One of my Dr.s' agreed today to put me on Naltrexone to see if it will help eleminate the cravings. Is it safe to drink alcoholic beverages such as wine or beer while taking the antiemetic drug Zofran? Although ondansetron may interact with several other medications with dangerously negative consequences, drinking alcohol while under treatment with it is not specifically contraindicated by its official prescribing information. You can pretty much guarantee your wheezing kid will become a puking one about 5 minutes after you give it. It's nasty!!! It's nasty!!! I actually tasted Orapred (just to see what it tasted like), and I didn't think it was bad at all.